This model was used to compare the nonlinearity of NMDA inputs between dendritic sections in a CA3 pyramidal neuron as well as investigate the effect of cholinergic modulation/potassium channel inhibition on this dendritic NMDA-mediated nonlinearity.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA3 pyramidal GLU cell
Currents: I Potassium
Transmitters: Acetylcholine
Model Concept(s): Active Dendrites; Dendritic Action Potentials; Detailed Neuronal Models; Neuromodulation
Simulation Environment: NEURON; Python
Implementer(s): Humphries, Rachel
References:
Humphries R, Mellor JR, O'Donnell C. (2022). Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model Neuroscience 489 [PubMed]