Model for pancreatic beta-cells with two isoforms of PFK (Marinelli et al., 2022)

This version of the Integrated Oscillator Model has two PFK isoforms, as well as modules for oxidative phosphorylation, electrical activity, and intracellular calcium.

Model Type: Neuron or other electrically excitable cell

Currents: ATP-senstive potassium current

Model Concept(s): Bursting

Simulation Environment: XPPAUT

Implementer(s): Bertram, Richard [rbertram at]


Marinelli I et al. (2022). Slow Oscillations Persist in Pancreatic Beta Cells Lacking Phosphofructokinase M Biophysical journal 121 [PubMed]