"We report here a mathematical model of SARS-CoV-2 infection pathway network with cytokine storm, oxidative stress, thrombosis, insulin resistance, and nitric oxide (NO) pathways. The biochemical systems theory model shows autocrine loops with positive feedback enabling excessive immune response, cytokines, transcription factors, and interferons, which can imbalance homeostasis of the system."
Model Type: Molecular Network
Model Concept(s): Signaling pathways; COVID-19
Simulation Environment: CellDesigner
Implementer(s): Sasidharakurup, Hemalatha [hemalathas at am.amrita.edu]; Diwakar, Shyam [shyam at amrita.edu]
References:
Sasidharakurup H, Kumar G, Nair B, Diwakar S. (2021). Mathematical Modeling of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Network with Cytokine Storm, Oxidative Stress, Thrombosis, Insulin Resistance, and Nitric Oxide Pathways OMICS. 25(12) [PubMed]