NEURON mod files from the paper: M. Migliore, L. Messineo, M. Ferrante Dendritic Ih selectively blocks temporal summation of unsynchronized distal inputs in CA1 pyramidal neurons, J.Comput. Neurosci. 16:5-13 (2004). The model demonstrates how the dendritic Ih in pyramidal neurons could selectively suppress AP generation for a volley of excitatory afferents when they are asynchronously and distally activated.
Model Type: Dendrite
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,t; I A; I K; I h
Receptors: AMPA
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Synchronization; Active Dendrites; Detailed Neuronal Models; Action Potentials
Simulation Environment: NEURON
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]
References:
Migliore M, Messineo L, Ferrante M. (2004). Dendritic Ih selectively blocks temporal summation of unsynchronized distal inputs in CA1 pyramidal neurons. Journal of computational neuroscience. 16 [PubMed]