An equivalent circuit model of the R15 bursting neuron in Aplysia has been combined with a fluid compartment model, resulting in a model that incorporates descriptions of most of the membrane ion channels that are known to exist in the somata of R15, as well as providing a Ca2+ balance on the cell. ... (from the second paper) we have implemented proposed mechanisms for the modulation of two ionic currents (IR and ISI) that play key roles in regulating its spontaneous electrical activity. The model was sufficient to simulate a wide range of endogenous activity in the presence of various concentrations of 5-HT or DA. See papers for more and details.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Aplysia R15 bursting neuron
Currents: I Na,t; I N; I K; I h; I Calcium
Model Concept(s): Bursting; Oscillations; Invertebrate
Simulation Environment: SNNAP
Implementer(s): Baxter, Douglas
References:
Butera RJ, Clark JW, Canavier CC, Baxter DA, Byrne JH. (1995). Analysis of the effects of modulatory agents on a modeled bursting neuron: dynamic interactions between voltage and calcium dependent systems. Journal of computational neuroscience. 2 [PubMed]
Canavier CC, Clark JW, Byrne JH. (1991). Simulation of the bursting activity of neuron R15 in Aplysia: role of ionic currents, calcium balance, and modulatory transmitters. Journal of neurophysiology. 66 [PubMed]