Detailed Markov models of IKs (the slow delayed rectifier K+ current) and its alpha-subunit KCNQ1 were developed. The model is compared to experiment in the paper. The role of IKs in disease and drug treatments is elucidated (the prevention of excessive action potential prolongation and development of arrhythmogenic early afterdepolarizations). See paper for more and details.
Model Type: Channel/Receptor
Genes: Kv1.9 Kv7.1 KCNQ1
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Action Potentials; Heart disease; Long-QT; Markov-type model
Simulation Environment: MATLAB (web link to model)
Implementer(s): Silva, Jonathan [jonsilva at gmail.com]
References:
Silva J, Rudy Y. (2005). Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation. 112 [PubMed]