Calcium sensitive large-conductance K channel conductance is controlled by both cytoplasmic calcium and membrane potential. Experimental data obtained by the inside out patch method can be understood in terms of a gating scheme where a central transition between a closed and an open conformation is allosterically regulated by the state of four independent and identical voltage sensors. See paper for more and details.
Model Type: Channel/Receptor
Currents: I K,Ca
Model Concept(s): Ion Channel Kinetics; Methods
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Chang, Han-Dong; Wu, Jiun-Shian [coolneon at gmail.com]
References:
Horrigan FT, Cui J, Aldrich RW. (1999). Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+). The Journal of general physiology. 114 [PubMed]