Detailed Markov model of IKs (the slow delayed rectifier K+ current) is supplied here in XPP. The model is compared to experiment in the paper. The role of IKs in disease and drug treatments is elucidated (the prevention of excessive action potential prolongation and development of arrhythmogenic early afterdepolarizations). See also modeldb accession number 55748 code and reference for more and details. This XPP version of the model reproduces Figure 3C in the paper by default. These model files were submitted by: Dr. Sheng-Nan Wu, Han-Dong Chang, Jiun-Shian Wu Department of Physiology National Cheng Kung University Medical College
Model Type: Channel/Receptor
Currents: I K; I Potassium; KCNQ1; I_Ks
Genes: Kv1.9 Kv7.1 KCNQ1
Transmitters: Ions
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Action Potentials; Heart disease; Long-QT; Markov-type model
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Chang, Han-Dong; Wu, Jiun-Shian [coolneon at gmail.com]
References:
Silva J, Rudy Y. (2005). Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation. 112 [PubMed]