Using patch clamp and modeling, we illustrate that spike latency characteristics are the product of an interplay between I(A) and low-threshold calcium current (I(T)) that requires a steady-state difference in the inactivation parameters of the currents. Furthermore, we show that the unique first-spike latency characteristics of stellate cells have important implications for the integration of coincident IPSPs and EPSPs, such that inhibition can shift first-spike latency to differentially modulate the probability of firing.
Model Type: Neuron or other electrically excitable cell
Currents: I Na,t; I T low threshold; I A; I K
Model Concept(s): Action Potential Initiation; Coincidence Detection
Simulation Environment: MATLAB
Implementer(s): Fernandez FR [ffernand at ucalgary.ca]; Mehaffey WH
References:
Molineux ML, Fernandez FR, Mehaffey WH, Turner RW. (2005). A-type and T-type currents interact to produce a novel spike latency-voltage relationship in cerebellar stellate cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]