Hippocampus temporo-septal engram shift model (Lytton 1999)

Temporo-septal engram shift model of hippocampal memory. The model posits that memories gradually move along the hippocampus from a temporal encoding site to ever more septal sites from which they are recalled. We propose that the sense of time is encoded by the location of the engram along the temporo-septal axis.

Model Type: Realistic Network

Region(s) or Organism(s): Hippocampus

Currents: I Na,t; I K

Receptors: GabaA; AMPA

Model Concept(s): Pattern Recognition; Temporal Pattern Generation; Spatio-temporal Activity Patterns; Simplified Models

Simulation Environment: NEURON

Implementer(s): Lytton, William [bill.lytton at downstate.edu]

References:

Lytton WW, Lipton P. (1999). Can the hippocampus tell time? The temporo-septal engram shift model. Neuroreport. 10 [PubMed]