The model simulations provide evidence oblique dendrites in CA1 pyramidal neurons are susceptible to hyper-excitability by amyloid beta block of the transient K+ channel, IA. See paper for details.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I K,Ca
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Pathophysiology; Aging/Alzheimer`s
Simulation Environment: NEURON
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Morse, Tom [Tom.Morse at Yale.edu]
References:
Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM. (2010). Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study. Frontiers in neural circuits. 4 [PubMed]