"(Edwards and Hirst 2006) provides an electrical description of the propagation of slow waves and pacemaker potentials in the guinea-pig gastric antrum in anal and circumferential directions. As electrical conduction between laterally adjacent circular muscle bundles is regularly interrupted, anal conduction of pacemaker potentials was assumed to occur via an electrically interconnected chain of myenteric interstitial cells of Cajal (ICCMY). ICCMY were also connected resistively to serially connected compartments of longitudinal muscle. Circumferential conduction occurred in a circular smooth muscle bundle that was represented as a chain of electrically connected isopotential compartments: each compartment contained a proportion of intramuscular interstitial cells of Cajal (ICCIM) that are responsible for the regenerative component of the slow wave. The circular muscle layer, which contains ICCIM, and the ICCMY network incorporated a mechanism, modelled as a two-stage chemical reaction, which produces an intracellular messenger. ... The model generates pacemaker potentials and slow waves with propagation velocities similar to those determined in the physiological experiments described in the accompanying paper."
Model Type: Realistic Network
Region(s) or Organism(s): Enteric nervous system
Cell Type(s): Myenteric interstitial cell of Cajal (ICCMY); Intramuscular interstitial cell of Cajal (ICCIM)
Model Concept(s): Temporal Pattern Generation; Oscillations; Spatio-temporal Activity Patterns
Simulation Environment: MATLAB
Implementer(s): Edwards, Frank [frank.edwards at anu.edu.au]
References:
Edwards FR, Hirst GD. (2006). An electrical analysis of slow wave propagation in the guinea-pig gastric antrum. The Journal of physiology. 571 [PubMed]
Hirst GD, Garcia-Londoño AP, Edwards FR. (2006). Propagation of slow waves in the guinea-pig gastric antrum. The Journal of physiology. 571 [PubMed]