"Hyperglycemia-related neuronal excitability and epileptic seizures are not uncommon in clinical practice. However, their underlying mechanism remains elusive. ATP-sensitive K(+) (K(ATP)) channels are found in many excitable cells, including cardiac myocytes, pancreatic beta cells, and neurons. These channels provide a link between the electrical activity of cell membranes and cellular metabolism. We investigated the effects of higher extracellular glucose on hippocampal K(ATP) channel activities and neuronal excitability. The cell-attached patch-clamp configuration on cultured hippocampal cells and a novel multielectrode recording system on hippocampal slices were employed. In addition, a simulation modeling hippocampal CA3 pyramidal neurons (Pinsky-Rinzel model) was analyzed to investigate the role of K(ATP) channels in the firing of simulated action potentials. ..."
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hippocampus CA3 pyramidal GLU cell
Currents: I K; I Potassium; ATP-senstive potassium current
Model Concept(s): Activity Patterns; Bursting; Oscillations; Action Potentials; Epilepsy
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Huang, Chin-Wei
References:
Huang CW, Huang CC, Cheng JT, Tsai JJ, Wu SN. (2007). Glucose and hippocampal neuronal excitability: role of ATP-sensitive potassium channels. Journal of neuroscience research. 85 [PubMed]