Synchronization by D4 dopamine receptor-mediated phospholipid methylation (Kuznetsova, Deth 2008)

"We describe a new molecular mechanism of dopamine-induced membrane protein modulation that can tune neuronal oscillation frequency to attention related gamma rhythm. This mechanism is based on the unique ability of D4 dopamine receptors (D4R) to carry out phospholipid methylation (PLM) that may affect the kinetics of ion channels. We show that by deceasing the inertia of the delayed rectifier potassium channel, a transition to 40 Hz oscillations can be achieved. ..."

Model Type: Realistic Network; Neuron or other electrically excitable cell; Synapse

Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell

Currents: I Na,t; I T low threshold; I K; I K,Ca

Transmitters: Dopamine

Model Concept(s): Activity Patterns; Oscillations; Synchronization; Simplified Models; Signaling pathways

Simulation Environment: XPPAUT

Implementer(s): Kuznetsova, Anna [anna.kuznetsova at]


Kuznetsova AY, Deth RC. (2008). A model for modulation of neuronal synchronization by D4 dopamine receptor-mediated phospholipid methylation. Journal of computational neuroscience. 24 [PubMed]

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