Here we showed experimentally that high frequency oscillations (up to 600 Hz) were easily induced in a purely gap-junction coupled network by simple two stimuli with very short interval. The root cause is that the second elicited spike suffered from slow propagation speed and failure to transmit through a low-conductance junction. Similiar results were also obtained in these simulation.
Model Type: Axon
Cell Type(s): Hodgkin-Huxley neuron
Model Concept(s): Action Potential Initiation; Axonal Action Potentials; Action Potentials; Delay; Conduction failure
Simulation Environment: NEURON
Implementer(s): Tseng, Shin-Hua
Tseng SH, Tsai LY, Yeh SR. (2008). Induction of high-frequency oscillations in a junction-coupled network. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]