A Model of Multiple Spike Initiation Zones in the Leech C-interneuron (Crisp 2009)

The leech C-interneuron and its electrical synapse with the S-interneuron exhibit unusual properties: an asymmetric delay when impulses travel from one soma to the other, and graded C-interneuron impulse amplitudes under elevated divalent cation concentrations. These properties have been simulated using a SNNAP model in which the C-interneuron has multiple, independent spike initiation zones associated with individual electrical junctions with the C-interneuron.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Leech C interneuron

Currents: I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium

Transmitters: Glutamate

Model Concept(s): Action Potential Initiation; Action Potentials

Simulation Environment: SNNAP

Implementer(s): Crisp, Kevin [crisp at stolaf.edu]


Crisp KM. (2009). Multiple spike initiation zones in a neuron implicated in learning in the leech: a computational model. Invertebrate neuroscience : IN. 9 [PubMed]

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