The leech C-interneuron and its electrical synapse with the S-interneuron exhibit unusual properties: an asymmetric delay when impulses travel from one soma to the other, and graded C-interneuron impulse amplitudes under elevated divalent cation concentrations. These properties have been simulated using a SNNAP model in which the C-interneuron has multiple, independent spike initiation zones associated with individual electrical junctions with the C-interneuron.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Leech C interneuron
Currents: I Na,p; I K; I K,leak; I K,Ca; I Sodium; I Calcium
Transmitters: Glutamate
Model Concept(s): Action Potential Initiation; Action Potentials
Simulation Environment: SNNAP
Implementer(s): Crisp, Kevin [crisp at stolaf.edu]
References:
Crisp KM. (2009). Multiple spike initiation zones in a neuron implicated in learning in the leech: a computational model. Invertebrate neuroscience : IN. 9 [PubMed]