This model investigates mechanisms contributing to short term plasticity at the calyx of Held, a giant glutamatergic synapse in the mammalian brainstem auditory system. It is a stochastic version of the model described in: Hennig, M., Postlethwaite, M., Forsythe, I.D. and Graham, B.P. (2007). A biophysical model of short-term plasticity at the calyx of Held. Neurocomputing, 70:1626-1629. This version introduces stochastic vesicle recycling and release. It has been used to investigate the information transmission properties of this synapse, as detailed in: Yang, Z., Hennig, M., Postlethwaite, M., Forsythe, I.D. and Graham, B.P. (2008). Wide-band information transmission at the calyx of Held. Neural Computation, 21(4):991-1018.
Model Type: Synapse
Region(s) or Organism(s): Auditory brainstem
Cell Type(s): Medial Nucleus of the Trapezoid Body (MNTB) neuron
Transmitters: Glutamate
Model Concept(s): Short-term Synaptic Plasticity; Vestibular
Simulation Environment: MATLAB
Implementer(s): Hennig, Matthias H [mhhennig at gmail.com]
References:
Yang Z, Hennig MH, Postlethwaite M, Forsythe ID, Graham BP. (2009). Wide-band information transmission at the calyx of Held. Neural computation. 21 [PubMed]
Forsythe ID, Graham BP, Hennig MH, Postlethwaite M. (2007). A biophysical model of short-term plasticity at the calyx of Held, Neurocomputing. 70(12)