STDP promotes synchrony of inhibitory networks in the presence of heterogeneity (Talathi et al 2008)

"Recently Haas et al. (J Neurophysiol 96: 3305–3313, 2006), observed a novel form of spike timing dependent plasticity (iSTDP) in GABAergic synaptic couplings in layer II of the entorhinal cortex. Depending on the relative timings of the presynaptic input at time tpre and the postsynaptic excitation at time tpost, the synapse is strengthened (delta_t = t(post) - t(pre) > 0) or weakened (delta_t < 0). The temporal dynamic range of the observed STDP rule was found to lie in the higher gamma frequency band (> or = 40 Hz), a frequency range important for several vital neuronal tasks. In this paper we study the function of this novel form of iSTDP in the synchronization of the inhibitory neuronal network. In particular we consider a network of two unidirectionally coupled interneurons (UCI) and two mutually coupled interneurons (MCI), in the presence of heterogeneity in the intrinsic firing rates of each coupled neuron. ..."

Model Type: Realistic Network

Region(s) or Organism(s): Entorhinal cortex

Currents: I Na,t; I K

Receptors: GabaA; Gaba

Model Concept(s): STDP

Simulation Environment: C or C++ program

Implementer(s): Talathi Sachin [talathi at ufl.edu]

References:

Talathi SS, Hwang DU, Ditto WL. (2008). Spike timing dependent plasticity promotes synchrony of inhibitory networks in the presence of heterogeneity. Journal of computational neuroscience. 25 [PubMed]