"We review here the development of Hodgkin- Huxley (HH) type models of cerebral cortex and thalamic neurons for network simulations. The intrinsic electrophysiological properties of cortical neurons were analyzed from several preparations, and we selected the four most prominent electrophysiological classes of neurons. These four classes are 'fast spiking', 'regular spiking', 'intrinsically bursting' and 'low-threshold spike' cells. For each class, we fit 'minimal' HH type models to experimental data. ..."
Model Type: Neuron or other electrically excitable cell; Channel/Receptor
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron
Currents: I Na,t; I L high threshold; I T low threshold; I K; I M
Model Concept(s): Parameter Fitting; Simplified Models
Simulation Environment: NEURON
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr]
References:
Pospischil M et al. (2008). Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons. Biological cybernetics. 99 [PubMed]