Hippocampus CA1: Temporal sensitivity of signaling pathways underlying LTP (Kim et al. 2010)

Temporal sensitivity of signaling pathways underlying L-LTP. Single compartment, deterministic model of calcium and dopamine activated pathways, leading to CaMKII and PKA activation. Experimental verification of model prediction.

Model Type: Synapse

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Receptors: Dopaminergic Receptor

Transmitters: Dopamine

Model Concept(s): Long-term Synaptic Plasticity; Signaling pathways

Simulation Environment: XPPAUT

Implementer(s): Blackwell, Avrama [avrama at gmu.edu]


Kim M, Huang T, Abel T, Blackwell KT. (2010). Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. PLoS computational biology. 6 [PubMed]

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