Uses a model of IP3-mediated release of Ca from endoplasmic reticulum (ER) to study how initiation and propagation of Ca waves are affected by cell geometry, spatial distributions of ER and IP3 generation, and diffusion of Ca and mobile buffer.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Unknown
Cell Type(s): Neuroblastoma
Currents: I_SERCA
Receptors: IP3
Model Concept(s): Calcium dynamics; Calcium waves
Simulation Environment: NEURON; Virtual Cell (web link to model)
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Fink, Charles C [cfink at uwm.edu]
References:
Fink CC et al. (2000). An image-based model of calcium waves in differentiated neuroblastoma cells. Biophysical journal. 79 [PubMed]