"The objective of this current study was to investigate whether voltage gated Ca(2+) channels are present on axons of the adult rat optic nerve (RON). Simulations of axonal excitability using a Hodgkin-Huxley based one-compartment model incorporating I(Na), I(K) and leak currents were used to predict conditions under which the potential contribution of a Ca(2+) current to an evoked action potential could be measured. ... , as predicted by the simulation, reducing the repolarizing effect of I(K) by adding the K(+) channel blocker 4-AP revealed a Ca(2+) component on the repolarizing phase of the action potential that was blocked by the Ca(2+) channel inhibitor nifedipine."
Model Type: Axon
Currents: I Na,t; I K; I Calcium
Model Concept(s): Simplified Models; Tutorial/Teaching; Axonal Action Potentials
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]
References:
Brown AM. (2003). A modeling study predicts the presence of voltage gated Ca2+ channels on myelinated central axons. Computer methods and programs in biomedicine. 71 [PubMed]