"... In this model, PFC dopamine is key for attentional learning, whereas basal ganglia dopamine, consistent with other models, is key for reinforcement and motor learning. The model assumes that competitive dynamics among PFC neurons is the neural mechanism underlying stimulus selection with limited attentional resources, whereas competitive dynamics among striatal neurons is the neural mechanism underlying action selection. According to our model, PD is associated with decreased phasic and tonic dopamine levels in both PFC and basal ganglia. ..."
Region(s) or Organism(s): Neocortex; Striatum
Model Concept(s): Parkinson's
Simulation Environment: MATLAB (web link to model)
References:
Gluck MA, Moustafa AA. (2011). A neurocomputational model of dopamine and prefrontal-striatal interactions during multicue category learning by Parkinson patients. J Cogn Neurosci. 23(1)