Single neuron with ion concentrations to model anoxic depolarization (Zandt et al. 2011)

A minimal single neuron model, including changing ion concentrations and homeostasis mechanisms. It shows the sudden depolarization that occurs after prolonged anoxia/ischemia.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Hodgkin-Huxley neuron

Currents: I Na,t; I K; I K,leak; Na/K pump; I Cl, leak; I Na, leak

Model Concept(s): Anoxic depolarization

Simulation Environment: MATLAB

Implementer(s): Zandt, Bas-Jan [Bas-Jan.Zandt at biomed.uib.no]

References:

Zandt BJ, ten Haken B, van Dijk JG, van Putten MJ. (2011). Neural dynamics during anoxia and the "wave of death". PloS one. 6 [PubMed]