Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)

" ... Previous one-dimensional network modeling of the cerebellar granular layer has been successfully linked with a range of cerebellar cortex oscillations observed in vivo. However, the recent discovery of gap junctions between Golgi cells (GoCs), which may cause oscillations by themselves, has raised the question of how gap-junction coupling affects GoC and granular-layer oscillations. To investigate this question, we developed a novel two-dimensional computational model of the GoC-granule cell (GC) circuit with and without gap junctions between GoCs. ..."

Model Type: Realistic Network

Region(s) or Organism(s): Cerebellum

Cell Type(s): Cerebellum interneuron granule GLU cell; Cerebellum golgi cell

Receptors: GabaA; AMPA; NMDA

Genes: HCN1; HCN2

Model Concept(s): Oscillations; Synchronization; Action Potentials

Simulation Environment: NEURON

Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br]


De Schutter E, Simoes-de-Souza FM. (2011). Robustness effect of gap junctions between Golgi cells on cerebellar cortex oscillations Neural Systems & Circuits. 1:7

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