Cortical pyramidal neuron, phase response curve (Stiefel et al 2009)

Three models of increasing complexity all showing a switch from type II (biphasic) to type I (monophasic) phase response curves with a cholinergic down-modulation of K+ conductances.

Cell Type(s): Neocortex L2/3 pyramidal GLU cell

Currents: I Na,p; I Na,t; I M

Receptors: Muscarinic

Transmitters: Acetylcholine

Model Concept(s): Action Potentials

Simulation Environment: NEURON

Implementer(s): Stiefel, Klaus [stiefel at salk.edu]

References:

Stiefel KM, Gutkin BS, Sejnowski TJ. (2009). The effects of cholinergic neuromodulation on neuronal phase-response curves of modeled cortical neurons. Journal of computational neuroscience. 26 [PubMed]