A multiphysics neuron model for cellular volume dynamics (Lee et al. 2011)

This paper introduces a novel neuron model, where the cell volume is a time-varying variable and multiple physical principles are combined to build governing equations. Using this model, we analyzed neuronal volume responses during excitation, which elucidated the waveforms of fast intrinsic optical signals observed experimentally across the literature. In addition, we analyzed volume responses on a longer time scale with repetitive stimulation to study the characteristics of slow cell swelling.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Hodgkin-Huxley neuron

Currents: I K; I Sodium; I_K,Na; Na/K pump; I Cl, leak; Osmosis-driven water flux

Receptors: Ion Receptors

Model Concept(s): Action Potentials; Cellular volume dynamics

Simulation Environment: MATLAB

Implementer(s): Antic, Srdjan [antic at neuron.uchc.edu]; Lee, Jonghwan [jonghwan at nmr.mgh.harvard.edu]


Lee J, Boas DA, Kim SJ. (2011). Multiphysics neuron model for cellular volume dynamics. IEEE transactions on bio-medical engineering. 58 [PubMed]

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