"Schizophrenia is characterized by cortical circuit abnormalities, which might be reflected in gamma-frequency (30–100 Hz) oscillations in the electroencephalogram. Here we used a computational model of cortical circuitry to examine the effects that neural circuit abnormalities might have on gamma generation and network excitability. The model network consisted of 1000 leaky integrateand- fi re neurons with realistic connectivity patterns and proportions of neuron types [pyramidal cells (PCs), regular-spiking inhibitory interneurons, and fast-spiking interneurons (FSIs)]. ... The results of this study suggest that a multimodal approach, combining non-invasive neurophysiological and structural measures, might be able to distinguish between different neural circuit abnormalities in schizophrenia patients. ..."
Model Type: Realistic Network
Region(s) or Organism(s): Neocortex
Model Concept(s): Oscillations; Simplified Models; Schizophrenia; Brain Rhythms
Simulation Environment: IDL
Implementer(s): Spencer, Kevin M. [kevin_spencer at hms.harvard.edu]
References:
Spencer KM. (2009). The functional consequences of cortical circuit abnormalities on gamma oscillations in schizophrenia: insights from computational modeling. Frontiers in human neuroscience. 3 [PubMed]