Gq coupled signaling pathways involved in striatal synaptic plasticity (Kim et al. 2013)

Model of Gq coupled signaling pathways underlying synaptic plasticity in striatal medium spiny projection neurons. Reactions and diffusion are implemented stochastically in a dendrite with one or more diffusionally coupled spines. Simulations demonstrate that theta burst stimulation, which produces LTP, increases the ratio of PKC:2AG as compared to 20 Hz stimulation, which produces LTD.

Model Type: Molecular Network

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell

Receptors: mGluR1

Model Concept(s): Synaptic Plasticity; Signaling pathways

Simulation Environment: NeuroRD

Implementer(s): Blackwell, Avrama [avrama at]


Kim B, Hawes SL, Gillani F, Wallace LJ, Blackwell KT. (2013). Signaling pathways involved in striatal synaptic plasticity are sensitive to temporal pattern and exhibit spatial specificity. PLoS computational biology. 9 [PubMed]

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