" ... In this modeling study we analyse how electrophysiological granule cell properties and spike sampling influence information coded by firing rate modulation, assuming no signal-related, i.e., uncorrelated inhibitory feedback (open-loop mode). A detailed one-compartment granule cell model was excited in simulation by either direct current or mossy-fiber synaptic inputs. Vestibular signals were represented as tonic inputs to the flocculus modulated at frequencies up to 20 Hz (approximate upper frequency limit of vestibular-ocular reflex, VOR). Model outputs were assessed using estimates of both the transfer function, and the fidelity of input-signal reconstruction measured as variance-accounted-for. The detailed granule cell model with realistic mossy-fiber synaptic inputs could transmit infoarmation faithfully and linearly in the frequency range of the vestibular-ocular reflex. ... "
Region(s) or Organism(s): Cerebellum
Cell Type(s): Cerebellum interneuron granule GLU cell
Rössert C, Solinas S, D'Angelo E, Dean P, Porrill J. (2014). Model cerebellar granule cells can faithfully transmit modulated firing rate signals. Frontiers in cellular neuroscience. 8 [PubMed]