This hippocampus model was developed by matching experimental data, including neuronal behavior, synaptic current dynamics, network spatial connectivity patterns, and short-term synaptic plasticity. Furthermore, it was constrained to perform pattern completion and separation under the effects of acetylcholine. The model was then used to investigate the role of short-term synaptic depression at the recurrent synapses in CA3, and inhibition by basket cell (BC) interneurons and oriens lacunosum-moleculare (OLM) interneurons in containing the unstable spread of excitatory activity in the network.
Model Type: Realistic Network
Region(s) or Organism(s): Hippocampus
Cell Type(s): Dentate gyrus granule GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron; Abstract Izhikevich neuron
Transmitters: Acetylcholine; Gaba; Glutamate
Model Concept(s): Activity Patterns; Epilepsy; Storage/recall
Simulation Environment: NEURON
References:
Hummos A, Franklin CC, Nair SS. (2014). Intrinsic mechanisms stabilize encoding and retrieval circuits differentially in a hippocampal network model. Hippocampus. 24 [PubMed]
Hummos A, Nair SS. (2017). An integrative model of the intrinsic hippocampal theta rhythm. PloS one. 12 [PubMed]