"... Using a 3D model of mitral and granule cell interactions supported by experimental findings, combined with a matrix-based representation of glomerular operations, we identify the mechanisms for forming one or more glomerular units in response to a given odor, how and to what extent the glomerular units interfere or interact with each other during learning, their computational role within the olfactory bulb microcircuit, and how their actions can be formalized into a theoretical framework in which the olfactory bulb can be considered to contain "odor operators" unique to each individual. ..."
Model Type: Realistic Network
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Active Dendrites; Synaptic Plasticity; Action Potentials; Synaptic Integration; Unsupervised Learning; Sensory processing; Olfaction
Simulation Environment: NEURON; Python
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]; Cavarretta, Francesco [francescocavarretta at hotmail.it]
References:
Migliore M et al. (2015). Synaptic clusters function as odor operators in the olfactory bulb. Proceedings of the National Academy of Sciences of the United States of America. 112 [PubMed]