To explore interactions between respiration, inhibition, and olfaction, experiments using light to active channel rhodopsin in sensory neurons expressing Olfactory Marker Protein were performed in mice and modeled in silico. This archive contains NEURON models that were run on parallel computers to explore the interactions between varying strengths of respiratory activity and olfactory sensory neuron input and the roles of periglomerular, granule, and external tufted cells in shaping mitral cell responses.
Region(s) or Organism(s): Olfactory bulb
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main tufted cell external
Simulation Environment: NEURON
Implementer(s): Morse, Tom [Tom.Morse at Yale.edu]
Short SM, Morse TM, McTavish TS, Shepherd GM, Verhagen JV. (2016). Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb. PloS one. 11 [PubMed]