Modeling epileptic seizure induced by depolarization block (Kim & Dykamp 2017)

"The inhibitory restraint necessary to suppress aberrant activity can fail when inhibitory neurons cease to generate action potentials as they enter depolarization block. We investigate possible bifurcation structures that arise at the onset of seizure-like activity resulting from depolarization block in inhibitory neurons. Networks of conductance based excitatory and inhibitory neurons are simulated to characterize different types of transitions to the seizure state, and a mean field model is developed to verify the generality of the observed phenomena of excitatory-inhibitory dynamics. ..."

Model Type: Realistic Network

Cell Type(s): Abstract Morris-Lecar neuron; Hodgkin-Huxley neuron

Model Concept(s): Epilepsy; Depolarization block

Simulation Environment: Brian

Implementer(s): Kim, Christopher M [christopher.kim3 at]


Kim CM, Nykamp DQ. (2017). The influence of depolarization block on seizure-like activity in networks of excitatory and inhibitory neurons. Journal of computational neuroscience. 43 [PubMed]

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