Respiratory control model with brainstem CPG and sensory feedback adapted for COVID-19 associated silent hypoxemia (Diekman et al., 2024)

Ben-Tal A, Smith JC. (2008). A model for control of breathing in mammals: coupling neural dynamics to peripheral gas exchange and transport. Journal of theoretical biology. 251 [PubMed]

Butera RJ, Rinzel J, Smith JC. (1999). Models of respiratory rhythm generation in the pre-Bötzinger complex. I. Bursting pacemaker neurons. Journal of neurophysiology. 82 [PubMed]

• Respiratory pacemaker neurons (Butera et al 1999) [Model]

Butera RJ, Rinzel J, Smith JC. (1999). Models of respiratory rhythm generation in the pre-Bötzinger complex. II. Populations Of coupled pacemaker neurons. Journal of neurophysiology. 82 [PubMed]

Carroll MS, Ramirez JM. (2013). Cycle-by-cycle assembly of respiratory network activity is dynamic and stochastic. Journal of neurophysiology. 109 [PubMed]

Cheng L, Ivanova O, Fan HH, Khoo MC. (2010). An integrative model of respiratory and cardiovascular control in sleep-disordered breathing. Respiratory physiology & neurobiology. 174 [PubMed]

Del Negro CA, Koshiya N, Butera RJ, Smith JC. (2002). Persistent sodium current, membrane properties and bursting behavior of pre-bötzinger complex inspiratory neurons in vitro. Journal of neurophysiology. 88 [PubMed]

Del Negro CA, Wilson CG, Butera RJ, Rigatto H, Smith JC. (2002). Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network. Biophysical journal. 82 [PubMed]

Diekman CO, Thomas PJ, Wilson CG. (2017). Eupnea, tachypnea, and autoresuscitation in a closed-loop respiratory control model. Journal of neurophysiology. 118 [PubMed]

• Respiratory control model with brainstem CPG and sensory feedback (Diekman, Thomas, and Wilson 2017) [Model]

GRODINS FS, GRAY JS, SCHROEDER KR, NORINS AL, JONES RW. (1954). Respiratory responses to CO2 inhalation; a theoretical study of a nonlinear biological regulator. Journal of applied physiology. 7 [PubMed]

Lindsey BG, Rybak IA, Smith JC. (2012). Computational models and emergent properties of respiratory neural networks. Comprehensive Physiology. 2 [PubMed]

Molkov YI, Rubin JE, Rybak IA, Smith JC. (2017). Computational models of the neural control of breathing. Wiley interdisciplinary reviews. Systems biology and medicine. 9 [PubMed]

Molkov YI et al. (2014). A closed-loop model of the respiratory system: focus on hypercapnia and active expiration. PloS one. 9 [PubMed]

Rubin JE, Shevtsova NA, Ermentrout GB, Smith JC, Rybak IA. (2009). Multiple rhythmic states in a model of the respiratory central pattern generator. Journal of neurophysiology. 101 [PubMed]

• Respiratory central pattern generator network in mammalian brainstem (Rubin et al. 2009) [Model]

Wang X et al. (2014). Laser ablation of Dbx1 neurons in the pre-Bötzinger complex stops inspiratory rhythm and impairs output in neonatal mice. eLife. 3 [PubMed]