Thalamocortical sleep model (Fink et. al., 2024, and Krishnan et al., 2016)

While many theoretical models of neural dynamics during sleep exist, few include the effects of neuromodulators on sleep oscillations and describe transitions between different states of vigilance. Here, we ported an established thalamocortical network model ( from C++ to NEURON. This model, which includes a biophysically realistic description of intrinsic and synaptic channels, allows for testing the effects of different neuromodulators, intrinsic cell properties, and synaptic connectivity on neural dynamics during sleep.

Model Type: Realistic Network

Region(s) or Organism(s): Neocortex; Thalamus

Cell Type(s):

Currents: I K; I K,Ca; I K,leak; I Na,p; I T low threshold; I h



Transmitters: Acetylcholine; Gaba; Glutamate; Histamine

Model Concept(s):

Simulation Environment: NEURON

Implementer(s): Fink, Christian G. [finkt at]


Krishnan GP et al. (2016). Cellular and neurochemical basis of sleep stages in the thalamocortical network. eLife. 5 [PubMed]

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