The existing electrical and intracellular calcium dynamics models are here combined into a comprehensive biophysically accurate description of olfactory transduction in AWCON neurons. The implemented codes simulate membrane voltage and intracellular calcium responses at different exposure times and odorant concentrations to grasp a complete picture of AWCON functioning. Moreover, the model permits to investigate the complex cascade of biochemical processes that allow AWC activation upon odor removal. Further, knock-out versions of the model suppressing different components are provided to extrapolate specific contributions to the overall neuron response.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s):
Cell Type(s): Abstract single compartment conductance based cell; C elegans AWCon; Hodgkin-Huxley neuron
Currents: I CNG; I Calcium; I Potassium; IK Bkca; IK Skca; Kir
Receptors:
Genes:
Transmitters:
Model Concept(s):
Simulation Environment: NEURON
Implementer(s): Nicoletti, Martina
References:
Nicoletti M et al. (2023). Modeling of olfactory transduction in AWCON neuron via coupled electrical-calcium dynamics. Biomolecular concepts. 14 [PubMed]