These files include a class definition for a sensory DRG pseudounipolar neuron model and a sensory DRG axon model, each of which can be instantiated for any value of fiber diameter in the continuous range [6, 20] um. The models are written in Python with pyNEURON. These models were used to investigate the effects of pseudounipolar neuron morphology and spatial distribution of neurons in the DRG on the selective activation of DRG A-alpha and A-beta sensory neurons in response to stimulation via two different types of electrodes (epineural and penetrating).
Model Type: Axon; Neuron or other electrically excitable cell
Region(s) or Organism(s):
Cell Type(s): Dorsal Root Ganglion (DRG) cell; Dorsal Root Ganglion cell: Spinal cord muscle spindle type II sensory fiber; Dorsal Root Ganglion cell: Spinal cord muscle spindle type Ia sensory fiber
Currents: I K; I K,leak; I Na, leak; I Na,p
Receptors:
Genes:
Transmitters:
Model Concept(s): Action Potential Initiation; Stimulus selectivity; Touch
Simulation Environment: NEURON; Python
References:
Farooqui J, Nanivadekar AC, Capogrosso M, Lempka SF, Fisher LE. (2024). The effects of neuron morphology and spatial distribution on the selectivity of dorsal root ganglion stimulation. Journal of neural engineering. 21 [PubMed]