Cerebellum granule cell FHF (Dover et al. 2016)

"Neurons in vertebrate central nervous systems initiate and conduct sodium action potentials in distinct subcellular compartments that differ architecturally and electrically. Here, we report several unanticipated passive and active properties of the cerebellar granule cell's unmyelinated axon. Whereas spike initiation at the axon initial segment relies on sodium channel (Nav)-associated fibroblast growth factor homologous factor (FHF) proteins to delay Nav inactivation, distal axonal Navs show little FHF association or FHF requirement for high-frequency transmission, velocity and waveforms of conducting action potentials. ...'

Model Type: Axon; Dendrite

Region(s) or Organism(s): Cerebellum

Cell Type(s): Cerebellum interneuron granule GLU cell

Currents: I A; I Calcium; I K; I K,Ca; I M; I Na,p; I Na,t; I Potassium; I Sodium; Kir

Receptors: AMPA; Gaba; NMDA

Simulation Environment: NEURON

Implementer(s): Solinas, Sergio [solinas at unipv.it]; Subramaniyam, Sathyaa [sakthisathyaa at gmail.com]; D'Angelo, Egidio [dangelo at unipv.it]; Goldfarb, Mitchell goldfarb at genectr.hunter.cuny.edu]


Dover K et al. (2016). FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon. Nature communications. 7 [PubMed]

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