Spikelet generation and AP initiation in a L5 neocortical pyr neuron (Michalikova et al. 2017) Fig 1

The article by Michalikova et al. (2017) explores the generation of spikelets in cortical pyramidal neurons. The model cell, adapted from Hu et al. (2009), is a layer V pyramidal neuron. The cell is stimulated by fluctuating synaptic inputs and generates somatic APs and spikelets in response. The spikelets are initiated as APs at the AIS that do not activate the soma.

Model Type: Neuron or other electrically excitable cell; Axon

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I Na,t

Model Concept(s): Action Potentials; Electrotonus; Action Potential Initiation; Axonal Action Potentials

Simulation Environment: NEURON; Python

Implementer(s): Michalikova, Martina [tinka.michalikova at gmail.com]

References:

Michalikova M, Remme MW, Kempter R. (2017). Spikelets in Pyramidal Neurons: Action Potentials Initiated in the Axon Initial Segment That Do Not Activate the Soma. PLoS computational biology. 13 [PubMed]