Gamma oscillations in hippocampal interneuron networks (Bartos et al 2002)

To examine whether an interneuron network with fast inhibitory synapses can act as a gamma frequency oscillator, we developed an interneuron network model based on experimentally determined properties. In comparison to previous interneuron network models, our model was able to generate oscillatory activity with higher coherence over a broad range of frequencies (20-110 Hz). In this model, high coherence and flexibility in frequency control emerge from the combination of synaptic properties, network structure, and electrical coupling.

Model Type: Realistic Network

Region(s) or Organism(s): Hippocampus

Cell Type(s): Abstract Wang-Buzsaki neuron

Currents: I Na,t; I K

Receptors: GabaA

Model Concept(s): Activity Patterns; Oscillations; Synchronization; Synaptic Integration

Simulation Environment: NEURON

Implementer(s): Jonas, Peter [Peter.Jonas at ist.ac.at]

References:

Bartos M et al. (2002). Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. Proceedings of the National Academy of Sciences of the United States of America. 99 [PubMed]