Glutamate-evoked Ca2+ oscillations in single astrocytes (Modified from Dupont et al. 2011)

We tested the reproducibility and comparability of four astrocyte models (Manninen, Havela, Linne, 2017). Model by Dupont et al. (2011) was one of them, but we had to modify the model to get more similar results as in the original publication. We implemented and ran the modified model using Jupyter Notebook. Model code produces results of Figure 1 and Figures 3-5 in Manninen, Havela, Linne (2017).

Model Type: Glia

Region(s) or Organism(s): Generic

Cell Type(s): Astrocyte

Receptors: IP3; mGluR5

Transmitters: Glutamate

Model Concept(s): Calcium dynamics; Oscillations; Signaling pathways

Simulation Environment: Python

Implementer(s): Manninen, Tiina [tiina.h.manninen at]


Manninen T, Havela R, Linne M-L. (2017). Reproducibility and comparability of computational models for astrocyte calcium excitability Front. Neuroinform..

Dupont G, Lokenye EF, Challiss RA. (2011). A model for Ca2+ oscillations stimulated by the type 5 metabotropic glutamate receptor: an unusual mechanism based on repetitive, reversible phosphorylation of the receptor. Biochimie. 93 [PubMed]

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