Temporal integration and 1/f power scaling in a circuit model of cerebellar interneurons (Maex and Gutkin 2017)

This is a circuit model of stellate/basket cells in the molecular layer of cerebellar cortex. The neurons have an active soma and passive 21-compartment dendrite. They are coupled electrically and via GABAA receptor synapses. We show that such an inhibitory circuit can produce slow response components (integration times up to 1.5 seconds), as predicted in a classical paper by Cannon, Robinson and Shamma (Biological Cybernetics 1983).

Model Type: Realistic Network

Region(s) or Organism(s): Cerebellum

Currents: I h; I K,Ca; I Na,t; I Calcium; I Potassium

Receptors: GabaA; AMPA

Transmitters: Gaba; Glutamate

Simulation Environment: GENESIS

Implementer(s): Maex, Reinoud [reinoud at bbf.uia.ac.be]

References:

Maex R, Gutkin B. (2017). Temporal integration and 1/f power scaling in a circuit model of cerebellar interneurons. Journal of neurophysiology. 118 [PubMed]