" ... Place fields could be produced in vivo in a single trial by potentiation of input that arrived seconds before and after complex spiking.The potentiated synaptic input was not initially coincident with action potentials or depolarization.This rule, named behavioral timescale synaptic plasticity, abruptly modifies inputs that were neither causal nor close in time to postsynaptic activation. ...", " ... To determine if the above plasticity rule could be observed under more realistic model conditions, we constructed and optimized a biophysically detailed model and attempted to fully account for the experimental data. ... "
Model Type: Synapse
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Model Concept(s): Hebbian plasticity; Action Potentials; Synaptic Plasticity; Calcium dynamics; Learning; Place cell/field
Simulation Environment: NEURON (web link to model)
Implementer(s): Milstein, Aaron D. [aaronmil at stanford.edu]
References:
Bittner KC, Milstein AD, Grienberger C, Romani S, Magee JC. (2017). Behavioral time scale synaptic plasticity underlies CA1 place fields. Science (New York, N.Y.). 357 [PubMed]