Effect of cortical D1 receptor sensitivity on working memory maintenance (Reneaux & Gupta 2018)

Alterations in cortical D1 receptor density and reactivity of dopamine-binding sites, collectively termed as D1 receptor-sensitivity in the present study, have been experimentally shown to affect the working memory maintenance during delay-period. However, computational models addressing the effect of D1 receptor-sensitivity are lacking. A quantitative neural mass model of the prefronto-mesoprefrontal system has been proposed to take into account the effect of variation in cortical D1 receptor-sensitivity on working memory maintenance during delay. The model computes the delay-associated equilibrium states/operational points of the system for different values of D1 receptor-sensitivity through the nullcline and bifurcation analysis. Further, to access the robustness of the working memory maintenance during delay in the presence of alteration in D1 receptor-sensitivity, numerical simulations of the stochastic formulation of the model are performed to obtain the global potential landscape of the dynamics.

Model Type: Neural mass

Region(s) or Organism(s): Prefrontal cortex (PFC)

Receptors: D1

Transmitters: Dopamine

Model Concept(s): Bifurcation; Stochastic simulation; Working memory; Schizophrenia

Simulation Environment: MATLAB

Implementer(s): Reneaux, Melissa [reneauxm5 at gmail.com]; Gupta, Rahul [gupta.sbt at gmail.com]


Reneaux M, Gupta R. (2018). Prefronto-cortical dopamine D1 receptor sensitivity can critically influence working memory maintenance during delayed response tasks PLOS ONE. 13(5)

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.