"In cerebellar Purkinje neuron (PN) dendrites, the transient depolarisation associated with a climbing fibre (CF) EPSP activates voltage-gated Ca2+ channels (VGCCs), voltage-gated K+ channels (VGKCs) and Ca2+ activated SK and BK K+ channels. The resulting membrane potential (Vm) and Ca2+ transients play a fundamental role in dendritic integration and synaptic plasticity of parallel fibre inputs. Here we report a detailed investigation of the kinetics of dendritic Ca2+ and K+ channels activated by CF-EPSPs, based on optical measurements of Vm and Ca2+ transients and on a single-compartment NEURON model reproducing experimental data. ... "
Model Type: Dendrite
Region(s) or Organism(s): Cerebellum
Cell Type(s): Cerebellum Purkinje GABA cell
Simulation Environment: NEURON
Implementer(s): Filipis, Luiza [luizafilipu at gmail.com]
Ait Ouares K, Filipis L, Tzilivaki A, Poirazi P, Canepari M. (2019). Two Distinct Sets of Ca2+ and K+ Channels Are Activated at Different Membrane Potentials by the Climbing Fiber Synaptic Potential in Purkinje Neuron Dendrites. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39 [PubMed]