We develop a new biophysically rooted, physiologically constrained conductance-based synaptic model to mechanistically account for short-term facilitation and depression, respectively through residual calcium and transmitter depletion kinetics. The model exhibits different synaptic filtering profiles upon changing certain parameters in the base model. We show degenercy in achieving similar plasticity profiles with different presynaptic parameters. Finally, by virtually knocking out certain conductances, we show the differential contribution of conductances.
Model Type: Synapse
Cell Type(s): Hippocampus CA3 pyramidal GLU cell
Receptors: AMPA
Model Concept(s): Conductance distributions; Short-term Synaptic Plasticity; Calcium dynamics; Neurotransmitter dynamics
Simulation Environment: NEURON
Implementer(s): Mukunda, Chinmayee L [chinmayeelm at gmail.com]
References:
Mukunda CL, Narayanan R. (2017). Degeneracy in the regulation of short-term plasticity and synaptic filtering by presynaptic mechanisms. The Journal of physiology. 595 [PubMed]