Compartmental differences in cAMP signaling pathways in hippocam. CA1 pyr. cells (Luczak et al 2017)

Model of cAMP signaling pathways in hippocampal CA1 pyramidal neurons investigate mechanisms underlying the experimentally observed difference in cAMP and PKA FRET between proximal and distal dendrites. Simulations show that compartmental difference in PKA activity required enrichment of protein phosphatase in small compartments; neither reduced PKA subunits nor increased PKA substrates were sufficient.

Model Type: Molecular Network

Region(s) or Organism(s): Hippocampus; Mouse

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Receptors: Adrenergic

Transmitters: Norephinephrine

Model Concept(s): G-protein coupled; Influence of Dendritic Geometry; Reaction-diffusion

Implementer(s): Blackwell, Avrama [avrama at]


Luczak V, Blackwell KT, Abel T, Girault JA, Gervasi N. (2017). Dendritic diameter influences the rate and magnitude of hippocampal cAMP and PKA transients during ß-adrenergic receptor activation. Neurobiology of learning and memory. 138 [PubMed]

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