Persistent Spiking in ACC Neurons (Ratte et al 2018)

"Neurons use action potentials, or spikes, to encode information. Some neurons can store information for short periods (seconds to minutes) by continuing to spike after a stimulus ends, thus enabling working memory. This so-called “persistent” spiking occurs in many brain areas and has been linked to activation of canonical transient receptor potential (TRPC) channels. However, TRPC activation alone is insufficient to explain many aspects of persistent spiking such as resumption of spiking after periods of imposed quiescence. Using experiments and simulations, we show that calcium influx caused by spiking is necessary and sufficient to activate TRPC channels and that the ensuing positive feedback interaction between intracellular calcium and TRPC channel activation can account for many hitherto unexplained aspects of persistent spiking."

Model Type: Neuron or other electrically excitable cell

Currents: I CAN; I_AHP; I Na,t; I K

Model Concept(s): Calcium dynamics; Action Potentials; Working memory; Persistent activity

Simulation Environment: XPPAUT

Implementer(s): Prescott, Steven [steve.prescott at]]


Ratté S, Karnup S, Prescott SA. (2018). Nonlinear Relationship Between Spike-Dependent Calcium Influx and TRPC Channel Activation Enables Robust Persistent Spiking in Neurons of the Anterior Cingulate Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.